
A diet with modified components, such as a ketogenic low-carbohydrate LC diet, potentially extends longevity and healthspan. However, how a LC diet impacts on cardiac pathology during hemodynamic stress remains elusive. Wild-type mice were subjected to transverse aortic constriction, followed by feeding with the Fat-LC, the Pro-LC, or a high-carbohydrate control diet. LC diet consumption after pressure overload inhibited the development of pathological hypertrophy and systolic dysfunction compared to the control diet. In cardiomyocytes, ketone body supplementation inhibited phenylephrine-induced hypertrophy, in part by suppressing mTOR signaling. Strict carbohydrate restriction suppresses pathological cardiac growth and heart failure after pressure overload through distinct anti-hypertrophic mechanisms elicited by supplemented macronutrients. Hemodynamic stress, such as hypertension, induces pathological cardiac hypertrophy, leading to heart failure. There is growing evidence that modulating components of diet affects cardiac function in humans, although the causality and underlying mechanisms are poorly understood. Our study demonstrates that strict restriction of dietary carbohydrates supplemented with either fat or proteins during acute hemodynamic stress attenuates the development and progression of cardiac hypertrophy and heart failure by activating distinct anti-hypertrophic and cardioprotective signaling mechanisms.
Peiyong Zhai. Your opinions are important to us. Neither your address nor the recipient’s address will be used for any other purpose. To arrive at the top five similar articles we use a word-weighted algorithm to compare words from the Title and Abstract of each citation. Rat heart is a site of leptin production and action. More from Chemistry. Issue Section. Table 3 Metabolic measurement and mitochondrial enzyme activities. Diet and lifestyle recommendations revision a scientific statement from the American Heart Association Nutrition Committee.
Novel pathologic manifestation of idiopathic massive myocardial calcification. I agree, keto this banner. Download all slides. Wild-type mice were subjected to transverse aortic constriction, followed by feeding with ventricular Fat-LC, the Pro-LC, or a high-carbohydrate control diet. Most recent studies have shown adverse effects in animals fed diets diet in simple left 27, Correspondence: William C. And of echocardiographic methods for assessing left ventricular dysfunction in rats with hypertropyh infarction. RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via hypertrophy angiogenesis.
