
They found that fructose and glucose, when added to a high fat diet, affect mechanisms in the liver in opposite ways. Kleiner, E. We found that HFr supplied in drinking water with a HF diet successfully induced both intrahepatic fat deposition and inflammation. Note: Content may be edited for style and length. Conclusions : The feeding with both high fructose and high-fat diet might cause the deterioration in the brain mainly the hypothalamus, and increased advanced glycation end products may play an essential role in the development of damage. The most important takeaway of this study is that high fructose in the diet is bad. Recent years, more scientific interest in how can diet effect on brain function has emerged. Related Stories. ACADL is responsible for beta-oxidation of fatty acids within the mitochondria. Volume 92 Next.
Damaging diet for mitochondria. All experiments were performed in.
Researchers at Joslin Diabetes Center have found that high levels of fructose in the diet inhibit the liver’s ability to properly metabolize fat. This effect is specific to fructose. Indeed, equally high levels of glucose in the diet actually improve the fat-burning function of the liver. This explains why high dietary fructose has more negative health impacts than glucose does, even though they have the same caloric content. It acts almost like adding more fat to the diet. This contrasts the effect of adding more glucose to the diet, which promotes the liver’s ability to burn fat, and therefore actually makes for a healthier metabolism. As a result, adding fructose to the diet makes the liver store more fat, and this is bad for the liver and bad for whole body metabolism. In fact, if anything, overall metabolism is somewhat better than if they just were on plain high-fat diet. In a series of animal studies, the Joslin researchers compared effects on metabolism of six different diets: regular chow, chow with high fructose, chow with high glucose, a high-fat diet, a high-fat diet with high fructose, and a high-fat diet with high glucose. The researchers analyzed different known markers of fatty liver to determine the effects of each diet. For example, they looked at levels of acylcarnitines in the liver’s cells.
Diet and high fat high fructose
Researchers at Joslin Diabetes Center have found that high levels of fructose in the diet inhibit the liver’s ability to properly metabolize fat. This effect is specific to fructose. Indeed, equally high levels of glucose in the diet actually improve the fat-burning function of the liver. This explains why high dietary fructose has more negative health impacts than glucose does, even though they have the same caloric content. It acts almost like adding more fat to the diet. This contrasts the effect of adding more glucose to the diet, which promotes the liver’s ability to burn fat, and therefore actually makes for a healthier metabolism. As a result, adding fructose to the diet makes the liver store more fat, and this is bad for the liver and bad for whole body metabolism. In fact, if anything, overall metabolism is somewhat better than if they just were on plain high-fat diet.
